人参皂苷 Rg3
人参皂苷 Rg3(Ginsenoside Rg3)
CAS: 14197-60-5;38243-03-7;11019-45-7
化学式: C42H72O13
| 中文名 | 人参皂苷 Rg3 |
| 英文名 | Ginsenoside Rg3 |
| 别名 | 人参皂苷Rg3 人参皂苷 Rg3 人参皂甙 Rg3 人参皂甙 RG3 人参皂苷单体RG3 人参皂苷 S-RG3 (R型)人参皂苷RG3 人参皂苷RG3(S型) 人参皂苷RG3(标准品) 20(S)-人参皂苷RG3 人参皂苷20(S)-RG3 |
| 英文别名 | Rg3 Ginsenoside Rg3 gensenoside RG3 opyransoyl)oxy)- (20S)-PROPANAXADIOL 20(R)-Propanaxadiol 20(s)-ginsenoside-rg3 eta-d-glucopyranosyl- Dammar-24-ene-12β,20-diol, 3β-[(2-O-β-D- dammar-24-ene-12-beta,20-diol,3-beta-((2-o-beta-d-glucopyranosyl-beta-d-gluc beta-d-glucopyranoside,(3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl2-o-b (3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside beta-D-Glucopyranoside,(3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl (5xi,8xi,9xi,12alpha,14beta,20R)-12,20-dihydroxylanost-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside (8xi,9xi,12alpha,14beta,17alpha)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,14-tetramethylgonan-3-yl 2-O-[3-deoxy-3-(hydroxymethyl)-beta-D-glucopyranosyl]-beta-D-glucopyranoside (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(10R,12S,13R,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxa (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-DIHYDROXY-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-HYDROXY-17-[(2S)-2-HYDROXY-6-METHYLHEPT-5-EN-2-YL]-4,4,8,10,14-PENTAMETHYL-2,3,5,6,7,9,11,12,13,15,16,17-DODECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-YL]OXY]-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL |
| CAS | 14197-60-5 38243-03-7 11019-45-7 |
| 化学式 | C42H72O13 |
| 分子量 | 785.03 |
| InChI | InChI=1/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,39-,40+,41+,42-/m0/s1 |
| InChIKey | RWXIFXNRCLMQCD-JBVRGBGGSA-N |
| 密度 | 1.30 |
| 熔点 | 315-318°C |
| 沸点 | 885.0±65.0 °C(Predicted) |
| 闪点 | 489.041°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | DMSO: ≥ 5 mg/mL |
| 折射率 | 1.594 |
| 酸度系数 | 12.85±0.70(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 粉末 |
| 颜色 | white to beige |
| 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。 |
| MDL号 | MFCD06410950 |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | 22 - 吞食有害。 |
| WGK Germany | 3 |
| RTECS | LY9537300 |
| 海关编号 | 29389090 |
| 参考资料 展开查看 | 1. 王萍 姬生威 朱晓东 罗红兰 付强.QHF复方对人肝癌Huh7细胞生长凋亡、侵袭能力的作用及其对肿瘤干细胞表面标志物的影响[J].胃肠病学和肝病学杂志 2018 27(10):1173-1176. 2. 付烊 张志丽 肖作为. QHF复方对肝癌细胞增殖的抑制作用及其机制[J]. 时珍国医国药 2016(11):2573-2575. 3. 钟雅婷 茅仁刚 宋纯清 等. RP-HPLC同时测定西洋参总皂苷转化产物中人参皂苷Rg1 Rh1 Rd Rg3和C-K的含量[J]. 江西中医药 2012 43(8):61-64. 4. 艾婷 周军 陈涛 胡卫 万信念 常俊杰.中药QHF复方对人乳腺癌MCF-7细胞的体外抗癌效果研究[J].中国全科医学 2014 17(15):1791-1794. 5. 荆鸣 朱春璐 袁子民 等. 人参皂苷Rg3聚合物胶束的工艺优化研究[J]. 中国民族民间医药 2017(15). 6. 唐玲, 叶立强, 王姣,等. 油茶皂素抗人胃癌SGC-7901细胞的活性研究[J]. 华西药学杂志 2014年29卷4期, 371-373页, ISTIC CSCD CA, 2014. 7. 韩铭鑫, 李方彤, 张琰,等. 稀有原人参二醇型皂苷的人肠道菌群生物转化[J]. 高等学校化学学报, 2019, 40(7). 8. 夏晚霞, 张尚微, 葛亚中,等. 乳酸菌发酵转化人参皂苷[J]. 现代食品科技, 2018, 34(09):136-142. 9. 李雪晴, 李丽, 刘秀峰,等. 三七皂苷的人肠道菌群体外代谢研究[J]. 药物生物技术, 2017(03):34-39. 10. 杨林, 徐晓珍, 陈劲柏,等. UHPLC法同时测定参麦注射液中8种人参皂苷[J]. 中成药, 2019. 11. 刘丹 焦良波 张文 王心怡 陈涛 胡卫.QHF复方对人肝癌Huh7细胞生长、侵袭及肿瘤干细胞表面标志物表达的影响[J].癌变·畸变·突变 2018 30(03):171-175. 12. 赵彩秀,王楠,黄鑫,越皓,郭云龙,刘淑莹.枯草芽孢杆菌JLGA-SD-28转化人参皂苷Rb1的特性及其全基因组测序分析[J].中成药,2021,43(02):518-523. 13. Wang, Zhihua, et al. "Comprehensive TCM molecular networking based on MS/MS in silico spectra with integration of virtual screening and affinity MS screening for discovering functional ligands from natural herbs." Analytical and bioanalytical chemistry 411 14. Teng, Siying, et al. "Effects of R type and S type ginsenoside Rg3 on DNA methylation in human hepatocarcinoma cells." Molecular medicine reports 15.4 (2017): 2029-2038.https://doi.org/10.3892/mmr.2017.6255 15. Chen, Tao, et al. "Chinese herbal formula QHF inhibits liver cancer cell invasion and migration." Experimental and Therapeutic Medicine 11.6 (2016): 2413-2419.https://doi.org/10.3892/etm.2016.3247 16. Cong, Zhongyi, et al. "Ginsenoside Rh3 inhibits proliferation and induces apoptosis of colorectal cancer cells." Pharmacology 105.5-6 (2020): 329-338.https://doi.org/10.1159/000503821 17. Chen, Jiali, et al. "Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology." LWT-Food Science and Technology 62.1 (2015): 517-524.https://doi.org/10.1016/j.lwt.2014.10.047 18. Zhang, Hong-Mei, et al. "Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach." Journal of pharmaceutical and biomedical analysis 62 (2012): 258-273.https://doi.org/10.1016/j.jpba.2012.01.010 19. Wang, Xiaoping, et al. "Baoyuan decoction ameliorates apoptosis via AT1-CARP signaling pathway in H9C2 cells and heart failure post-acute myocardial infarction rats." Journal of ethnopharmacology 252 (2020): 112536.https://doi.org/10.1016/j.jep.2019.112536 20. Manying Wang, Jixiang Ren, Xuenan Chen, Jianzeng Liu, Xiaohao Xu, Xiangyan Li, Daqing Zhao, Liwei Sun, 20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway, Biochemical Ph 21. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 22. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 23. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 24. Joo, Kyung-Mi, et al. "Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method." Journal of pharmaceutical and biomedical analysis 51.1 (20 25. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 26. [IF=6.06] Yang Xiu et al."Simultaneous determination and difference evaluation of 14 ginsenosides in Panax ginseng roots cultivated in different areas and ages by high-performance liquid chromatography coupled with triple quadrupole mass spectrometer in the multipl 27. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 28. [IF=4.952] Jiali Chen et al."Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology."Lwt Food Sci Technol. 2015 Jun;62:517 29. [IF=4.225] Yang Jing et al."Ginsenoside Rg3 Attenuates Lipopolysaccharide-Induced Acute Lung Injury via MerTK-Dependent Activation of the PI3K/AKT/mTOR Pathway."Front Pharmacol. 2018 Aug;0:850 30. [IF=3.935] Hong-Mei Zhang et al."Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach."J Pharmaceut Biomed. 2012 Mar;62:258 31. [IF=3.935] Hong Zhang et al."A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry for the analysis of ginsenosides from white a 32. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 33. [IF=2.952] Siying Teng et al."Effects of R type and S type ginsenoside Rg3 on DNA methylation in human hepatocarcinoma cells."Mol Med Rep. 2017 Apr;15(4):2029-2038 34. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 35. [IF=6.06] Zhenzhuo Li et al."Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes."J Ginseng Res. 2021 May;: 36. [IF=5.81] Zhang Silin et al."Ginsenoside Compound K Regulates HIF-1α-Mediated Glycolysis Through Bclaf1 to Inhibit the Proliferation of Human Liver Cancer Cells."Front Pharmacol. 2020 Dec;0:2050 37. [IF=5.396] Hui Wang et al."Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans."Food Funct. 2021 Aug;12(15):6793-6808 38. [IF=4.96] Manying Wang et al."20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway."Biochem Pharmacol. 2020 Oct;180:114145 39. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136 40. [IF=4.192] Yan Zhang et al."Ginsenoside Rg3 Alleviates Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Mice by Regulating CD4+CD25+Foxp3+Treg Cells."J Agr Food Chem. 2020;68(17):4893–4902 41. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 42. [IF=3.69] Xiaoping Wang et al."Baoyuan decoction ameliorates apoptosis via AT1-CARP signaling pathway in H9C2 cells and heart failure post-acute myocardial infarction rats."J Ethnopharmacol. 2020 Apr;252:112536 43. [IF=3.647] Wenqi Jin et al."Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells."Life Sci. 2020 Mar;245:117337 44. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 45. [IF=3.571] Yan Zhang et al."Ginsenoside Rg3 Prevents Cognitive Impairment by Improving Mitochondrial Dysfunction in the Rat Model of Alzheimer’s Disease."J Agr Food Chem. 2019;67(36):10048–10058 46. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 47. [IF=2.629] Zhang Meiyu et al."In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora."Evid-Based Compl Alt. 2021;2021:1735803 48. [IF=2.547] Zhongyi Cong et al."Ginsenoside Rh3 Inhibits Proliferation and Induces Apoptosis of Colorectal Cancer Cells."Pharmacology. 2020;105(5-6):329-338 49. [IF=2.408] Yan Zhao et al."Protective Effects of Ginsenosides (20R)-Rg3 on H2O2-Induced Myocardial Cell Injury by Activating Keap-1/Nrf2/HO-1 Signaling Pathway."Chem Biodivers. 2021 Apr;18(4):e2001007 50. [IF=2.408] Fang-Tong Li et al."In Vitro Effects of Ginseng and the Seed of Zizyphus jujuba var. spinosa on Gut Microbiota of Rats with Spleen Deficiency."Chem Biodivers. 2020 Sep;17(9):e2000199 51. [IF=2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis."Parasitol Res. 2021 Mar;120(3):1143-1150 52. [IF=3.105] Zhao Yan et al.Protopanaxadiol and Protopanaxatriol Ginsenosides Can Protect Against Aconitine-induced Injury in H9c2 Cells by Maintaining Calcium Homeostasis and Activating the AKT Pathway.J Cardiovasc Pharm. 2021 Nov;78(5):e690-e702 53. [IF=4.432] Shuai Zhang et al."Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy."Eur J Pharmacol. 2022 May;922:174887 54. [IF=2.419] Yinping Jin et al."Dynamic changes of ginsenosides in Panax quinquefolius fruit at different development stages measured by UHPLC-Orbitrap MS."Rapid Communications In Mass Spectrometry. 2022 Feb 17 55. [IF=6.06] Qingxia Huang et al."Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons."J Ginseng Res. 2022 Feb;: 56. [IF=5.34] Dong Shao et al."Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology."PHYTOMEDICINE. 2022 Jul;102:154177 57. [IF=6.576] Zhi-man Li et al."Transformation Mechanism of Rare Ginsenosides in American Ginseng by Different Processing Methods and Antitumour Effects."Frontiers in Nutrition. 2022; 9: 833859 58. [IF=6.576] Rensong Huang et al."Studies on Bioactive Components of Red Ginseng by UHPLC-MS and Its Effect on Lipid Metabolism of Type 2 Diabetes Mellitus."Frontiers in Nutrition. 2022; 9: 865070 59. [IF=1.885] Guo Na et al."Comparison of the Saponins in Three Processed American Ginseng Products by Ultra-High Performance Liquid Chromatography-Quadrupole Orbitrap Tandem Mass Spectrometry and Multivariate Statistical Analysis."International Journal of Analytical Ch |
人参皂苷 Rg3 - 简介
人参皂苷Rg3是一种来自于人参的天然化合物，属于人参皂苷家族中的一员。
性质：
人参皂苷Rg3是一种棕色的结晶性粉末，具有苦味。它属于糖苷类化合物，化学结构相对复杂。人参皂苷Rg3具有多种生物活性，包括抗氧化、抗炎、抗肿瘤和改善记忆等作用。
用途：
人参皂苷Rg3在药学和保健品工业中具有广泛的应用。它被认为能够增强人体免疫力、改善心血管健康、提高认知能力、延缓衰老以及抗肿瘤等。
制法：
人参皂苷Rg3可以通过萃取和纯化人参中的有效成分得到。一般来说，人参细胞内的二萜酯化合物会在酶的作用下转化为人参皂苷Rg3。
安全信息：
人参皂苷Rg3是一种天然化合物，可安全使用。
性质：
人参皂苷Rg3是一种棕色的结晶性粉末，具有苦味。它属于糖苷类化合物，化学结构相对复杂。人参皂苷Rg3具有多种生物活性，包括抗氧化、抗炎、抗肿瘤和改善记忆等作用。
用途：
人参皂苷Rg3在药学和保健品工业中具有广泛的应用。它被认为能够增强人体免疫力、改善心血管健康、提高认知能力、延缓衰老以及抗肿瘤等。
制法：
人参皂苷Rg3可以通过萃取和纯化人参中的有效成分得到。一般来说，人参细胞内的二萜酯化合物会在酶的作用下转化为人参皂苷Rg3。
安全信息：
人参皂苷Rg3是一种天然化合物，可安全使用。
最后更新：2024-04-09 15:16:35
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产品名: 人参皂苷Rg3(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IG02601
产地: 北京
包装: 1ml/瓶
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产品名: R-人参皂苷 Rg3 去供应商网站查看 询盘CAS: 38243-03-7
产地: 上海
规格: R823511
价格: 20mg-706,100mg-1956,25mg-741,5mg-308,1ml-710
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
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微信: 19863730987/17821173903
提供多种规格现货供应
产品名: 人参皂苷Rg3(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IG02601
产地: 北京
包装: 1ml/瓶
规格: IG02601-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
提供多种规格现货供应
产品名: R-人参皂苷 Rg3 去供应商网站查看 询盘CAS: 38243-03-7
产地: 上海
规格: R823511
价格: 20mg-706,100mg-1956,25mg-741,5mg-308,1ml-710
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
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